Plasma binding of 1-butanol, phenol, nitrobenzene and pentachlorophenol in the rainbow trout and rat: A comparative study

1. 1. The in vitro binding of 1-butanol, phenol, nitrobenzene, and pentachlorophenol in trout plasma and rat plasma was determined. 2. 2. Binding to rainbow trout plasma proteins agreed within 9% of that observed in rat plasma. 3. 3. Percentage bound to rainbow trout (2–99%) or rat (10–99%) plasma p...

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Published inComparative biochemistry and physiology. C, Comparative pharmacology Vol. 91; no. 2; pp. 413 - 418
Main Authors Schmieder, Patricia K., Henry, Tala R.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier B.V 1988
New York, NY Pergamon Press
Subjects
1-Butanol
Animals
Biological and medical sciences
Blood Proteins - metabolism
Butanols - blood
Chlorophenols - blood
Freshwater
General aspects. Methods
Medical sciences
Nitrobenzenes - blood
Pentachlorophenol - blood
Phenol
Phenols - blood
Protein Binding
Rats
Rats, Inbred Strains
Salmonidae - blood
Toxicology
Trout - blood
Toxicokinetics
Animal model
Binding protein
Vertebrata
Biological fixation
Mammalia
Rat
Pisces
Interspecific comparison
Rodentia
Metabolism physicochemical property relationship
Salmo gairdneri
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Summary:1. 1. The in vitro binding of 1-butanol, phenol, nitrobenzene, and pentachlorophenol in trout plasma and rat plasma was determined. 2. 2. Binding to rainbow trout plasma proteins agreed within 9% of that observed in rat plasma. 3. 3. Percentage bound to rainbow trout (2–99%) or rat (10–99%) plasma proteins increased as the log octanol/water partition coefficient of the chemicals increased within the Log P 1–3 range, and was suggestive of hydrophobic interactions in binding.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0306-4492
0742-8413
DOI:10.1016/0742-8413(88)90052-7