Study of myocardial contractility by pulsed wave doppler tissue imaging does not reveal an inotropic effect of estrogen at physiologic dose

We studied myocardial contractility by pulsed wave Doppler tissue imaging in 6 postmenopausal healthy women. According to a crossover, double-blind protocol, we randomized patients to treatment with transdermal patches of estradiol-17beta or matched placebo. Estradiol-17beta did not modify local sys...

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Bibliographic Details
Published inThe American journal of cardiology Vol. 83; no. 12; pp. 1677 - 1679
Main Authors Mercuro, Giuseppe, Zoncu, Sandra, Paoletti, Anna M., Melis, Gian Benedetto, Vacca, A.M.Beatrice, Cherchi, Angelo
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 15.06.1999
Elsevier
Elsevier Limited
Subjects
Administration, Cutaneous
Biological and medical sciences
Cross-Over Studies
Double-Blind Method
Effects
Estradiol - administration & dosage
Estradiol - blood
Estradiol - pharmacology
Estrogens
Female
Heart
Hemodynamics - drug effects
Hormones. Endocrine system
Humans
Medical imaging
Medical sciences
Middle Aged
Myocardial Contraction - drug effects
Pharmacology. Drug treatments
Postmenopause - physiology
Ultrasonography, Doppler, Pulsed
Sonography
Doppler ultrasound study
Human
Chemotherapy
Replacement therapy
Contractility
Estrogen
Myocardium
Postmenopause
Exploration
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Summary:We studied myocardial contractility by pulsed wave Doppler tissue imaging in 6 postmenopausal healthy women. According to a crossover, double-blind protocol, we randomized patients to treatment with transdermal patches of estradiol-17beta or matched placebo. Estradiol-17beta did not modify local systolic and diastolic functions. Thus, at least when acutely administered, estrogen seems to be unable to determine hemodynamic changes at the myocardial level, in opposition to what occurs in the peripheral vascular system.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00180-0