Effects of clozapine on ketamine-induced linguopharyngeal events in rats

We tested the effects of clozapine (0.02-20 mg/kg i.p.) on ketamine-induced linguopharyngeal events in rats anesthetized with i.m. injections of ketamine hydrochloride (100 mg/kg) and mounted on a stereotaxic with the tip of the tongue tied to a force displacement transducer monitoring tongue protru...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 164; no. 1; p. 171
Main Authors Marco, L A, Joshi, R S, Brigham, T E, Aldes, L D, Chronister, R B
Format Journal Article
LanguageEnglish
Published Netherlands 02.05.1989
Subjects
Animals
Clozapine - pharmacology
Deglutition - drug effects
Dibenzazepines - pharmacology
Dose-Response Relationship, Drug
Ketamine - pharmacology
Pharynx - drug effects
Pharynx - physiology
Rats
Rats, Inbred Strains
Tongue - drug effects
Tongue - physiology
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Summary:We tested the effects of clozapine (0.02-20 mg/kg i.p.) on ketamine-induced linguopharyngeal events in rats anesthetized with i.m. injections of ketamine hydrochloride (100 mg/kg) and mounted on a stereotaxic with the tip of the tongue tied to a force displacement transducer monitoring tongue protrusions, retrusions and swallows. Reduction began at the 0.04 mg/kg dose. At 4.8 mg/kg there was total suppression of events. At 20 mg/kg, suppression lasted for 1 h. Notably clozapine doses causing total suppression of events in our model were much lower than those usually reported to alter dopamine turnover.
ISSN:0014-2999
DOI:10.1016/0014-2999(89)90246-X