Roles of lipid droplets and related proteins in metabolic diseases

• Published in: Lipids in health and disease Vol. 23; no. 1; pp. 218 - 19
• Main Authors: Zhang, Zhongyang, Yu, Zhenghang, Liang, Dianyuan, Song, Ke, Kong, Xiangxin, He, Ming, Liao, Xinxin, Huang, Ziyan, Kang, Aijia, Bai, Rubing, Ren, Yixing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.07.2024; BioMed Central; BMC
• Subjects: Animals; Autophagy; Biosynthesis; Cell organelles; Development and progression; Endoplasmic Reticulum - metabolism; Health aspects; Humans; Lipid droplet; Lipid Droplets - metabolism; Lipid Metabolism; Lipids; Liver diseases; Medical research; Medicine, Experimental; Metabolic diseases; Metabolic Diseases - metabolism; Metabolic Diseases - pathology; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Obesity - metabolism; Physiological aspects; Post-translational modification; Proteins; rab GTP-Binding Proteins - metabolism; Review; China; Metabolic diseases; Lipid droplet; Lipid metabolism
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-024-02212-y

Lipid droplets (LDs), which are active organelles, derive from the monolayer membrane of the endoplasmic reticulum and encapsulate neutral lipids internally. LD-associated proteins like RAB, those in the PLIN family, and those in the CIDE family participate in LD formation and development, and they are active players in various diseases, organelles, and metabolic processes (i.e., obesity, non-alcoholic fatty liver disease, and autophagy). Our synthesis on existing research includes insights from the formation of LDs to their mechanisms of action, to provide an overview needed for advancing research into metabolic diseases and lipid metabolism.