Autoantibodies in pathology and cell biology

A common feature of autoimmune diseases is a humoral immune response manifested by the presence of autoantibodies targeted against cellular proteins and nucleic acids that play the role of antigens. An underlying goal in the characterization of the molecular structure and identity of autoantigens is...

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Bibliographic Details
Published inCell Vol. 67; no. 5; pp. 841 - 842
Main Author Tan, Eng M.
Format Book Review Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Inc 29.11.1991
Cell Press
Subjects
Autoantibodies - physiology
Autoantigens - immunology
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmunity (experimental aspects and models)
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Lupus Erythematosus, Systemic - immunology
Scleroderma, Systemic - immunology
Sjogren's Syndrome - immunology
Autoantibody
Autoimmune disease
Autoantigen
Review
Molecular structure
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Summary:A common feature of autoimmune diseases is a humoral immune response manifested by the presence of autoantibodies targeted against cellular proteins and nucleic acids that play the role of antigens. An underlying goal in the characterization of the molecular structure and identity of autoantigens is the anticipation that such information might help to determine the etiological and pathogenic mechanisms that induce autoimmunity. Although definitive answers are not yet available, current knowledge provides compelling reasons for considering the mechanisms of autoimmune diseases.
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ISSN:0092-8674
1097-4172
DOI:10.1016/0092-8674(91)90356-4