Are germ cell tumors part of the Li-Fraumeni cancer family syndrome?

The occurrence of six cases of germ cell tumors, five testicular and one ovarian, in relatives of children with bone or soft tissue sarcomas is described. It is proposed that germ cell tumors may be an uncommon manifestation of the genetic predisposition to cancer that exists in the Li-Fraumeni canc...

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Bibliographic Details
Published inCancer genetics and cytogenetics Vol. 42; no. 2; pp. 221 - 226
Main Authors Hartley, Ann L., Birch, Jillian M., Kelsey, Anna M., Marsden, Henry B., Harris, Martin, Teare, Marion D.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 15.10.1989
Elsevier Science
Subjects
Adult
Biological and medical sciences
Breast Neoplasms - genetics
carcinoma
Child
Diseases of the osteoarticular system
Dysgerminoma - genetics
Female
germ cells
Humans
Infant
Male
Medical sciences
Middle Aged
Neoplastic Syndromes, Hereditary - genetics
Ovarian Neoplasms - genetics
Sarcoma - genetics
Soft Tissue Neoplasms - genetics
Syndrome
Testicular Neoplasms - genetics
Tumors of striated muscle and skeleton
tumours
Human
Sarcoma
Family study
Diseases of the osteoarticular system
Hereditary
Testicle
Genital diseases
Germ cell tumor
Ovarian diseases
Ovary
Predisposition
Li Fraumeni cancer family syndrome
Tumor
Soft tissue
Bone
Child
Testicular diseases
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Summary:The occurrence of six cases of germ cell tumors, five testicular and one ovarian, in relatives of children with bone or soft tissue sarcomas is described. It is proposed that germ cell tumors may be an uncommon manifestation of the genetic predisposition to cancer that exists in the Li-Fraumeni cancer family syndrome.
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ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(89)90090-3