Chronic neuroleptic administration decreases extracellular GABA in the nucleus accumbens but not in the caudate-putamen of rats

The extracellular levels of gamma-aminobutyric acid (GABA) in the caudate-putamen and the nucleus accumbens of rats following administration of haloperidol decanoate, fluphenazine decanoate, or vehicle for 8 months were assessed using intracranial microdialysis. Basal levels of extracellular GABA we...

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Bibliographic Details
Published inBrain research Vol. 588; no. 1; p. 177
Main Authors See, R E, Chapman, M A, Klitenick, M A
Format Journal Article
LanguageEnglish
Published Netherlands 14.08.1992
Subjects
Animals
Antipsychotic Agents - pharmacology
Caudate Nucleus - drug effects
Caudate Nucleus - metabolism
Dialysis
Female
Fluphenazine - pharmacology
gamma-Aminobutyric Acid - metabolism
Haloperidol - pharmacology
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Putamen - drug effects
Putamen - metabolism
Rats
Rats, Sprague-Dawley
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Summary:The extracellular levels of gamma-aminobutyric acid (GABA) in the caudate-putamen and the nucleus accumbens of rats following administration of haloperidol decanoate, fluphenazine decanoate, or vehicle for 8 months were assessed using intracranial microdialysis. Basal levels of extracellular GABA were significantly decreased in the nucleus accumbens of both neuroleptic-treated groups while levels of GABA in the caudate-putamen were not significantly different between groups. These results provide evidence for selective chronic neuroleptic-induced effects on in vivo GABA function in different terminal regions containing dopamine receptors.
ISSN:0006-8993
DOI:10.1016/0006-8993(92)91361-H