Molecular analysis of human class II transplantation antigens and their genes

• Published in: Human immunology Vol. 8; no. 1; pp. 95 - 103
• Main Authors: Larhammar, D., Andersson, G., Andersson, M., Bill, P., Böhme, J., Claesson, L., Denaro, M., Emmoth, E., Gustafsson, K., Hammarling, U., Heldin, E., Hyldig-Nielsen, J.J., Lind, P., Schenning, L., Servenius, B., Widmark, E., Rask, L., Peterson, P.A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.1983; Elsevier Science
• Subjects: Amino Acid Sequence; Biological and medical sciences; Biological Transport; Cloning, Molecular; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genes; Genes, MHC Class II; Genetics of the immune response; Humans; Immunobiology; Macromolecular Substances; Major Histocompatibility Complex; Membrane Proteins - genetics; Polymorphism, Genetic; Human; HLA-System; Recombination; Histocompatibility system; Cell-cell interaction; Primary structure; Homotransplantation; Antigen; Allele; Immunogenetics; Complementary DNA; Gene; Molecular cloning
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/0198-8859(83)90087-3

Recombinant DNA techniques now offer new means to characterize the class II antigens, in regards to structure, genetic polymorphism, and, eventually, function. Using cloned cDNA, it has already been possible to gain some insight into the number of class II antigen loci, the distribution of variant amino acids among allelic forms of class II antigens, and the organization of archetypal genes for class II antigens. In this communication, the authors will briefly summarize some of their data on these points.