1-Methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a newly described neurotoxin which selectively destroys cells in the substantia nigra when administered systemically to primates. Because the substance creates a condition in humans which is virtually indistinguishable from Parkinson's dise...

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Bibliographic Details
Published inNeuroscience letters Vol. 48; no. 1; p. 87
Main Authors Langston, J W, Irwin, I, Langston, E B, Forno, L S
Format Journal Article
LanguageEnglish
Published Ireland 13.07.1984
Subjects
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-Methyl-4-phenylpyridinium
Animals
Biotransformation
Brain - metabolism
Chromatography, High Pressure Liquid
Male
Pyridines - metabolism
Pyridines - toxicity
Pyridinium Compounds - metabolism
Saimiri
Substantia Nigra - drug effects
Substantia Nigra - metabolism
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Summary:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a newly described neurotoxin which selectively destroys cells in the substantia nigra when administered systemically to primates. Because the substance creates a condition in humans which is virtually indistinguishable from Parkinson's disease, interest has focused on its mechanism of action. We now report that MPTP appears to be rapidly metabolized after systemic administration in toxic amounts, and identify 1-methyl-4-phenylpyridinium ion (MPP+) as a probable major metabolite.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(84)90293-3