The neurotoxicity of intrahippocampal kainic acid injection in rats is not accompanied by a reduction of Timm stain

Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectabl...

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Bibliographic Details
Published inBrain research Vol. 449; no. 1-2; p. 341
Main Authors Théorêt, Y, Earnhardt, T S, Bouldin, T W, Krigman, M R
Format Journal Article
LanguageEnglish
Published Netherlands 24.05.1988
Subjects
Animals
Hippocampus - drug effects
Hippocampus - pathology
Kainic Acid - toxicity
Male
Neurons - cytology
Neurons - drug effects
Pyramidal Tracts - drug effects
Pyramidal Tracts - pathology
Rats
Staining and Labeling
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Summary:Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectable loss of histologically demonstrable zinc as assessed by means of a modified Timm's sulphide-silver method. It is suggested that the selective injury of hippocampal neurons induced by kainic acid is not contingent on the release of zinc from mossy-fiber terminals.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(88)91050-5