Human renin: A new class of inhibitors

A new class of human renin inhibitor is described, containing a novel analogue of the peptide bond. High inhibitory potency was observed for octapeptide-length substrate analogues but inhibition progressively weakened as the molecule was shortened from the amino terminal end.

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 134; no. 1; pp. 71 - 77
Main Authors Dann, J.G., Stammers, D.K., Harris, C.J., Arrowsmith, R.J., Davies, D.E., Hardy, G.W., Morton, J.A.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 14.01.1986
Elsevier
Subjects
Amino Acid Sequence
Angiotensinogen - metabolism
Applied sciences
Exact sciences and technology
Humans
Kinetics
man
Mathematics
Oligopeptides - pharmacology
Other techniques and industries
Renin - antagonists & inhibitors
renin inhibitor
Structure-Activity Relationship
TDP
Z
SEM
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Summary:A new class of human renin inhibitor is described, containing a novel analogue of the peptide bond. High inhibitory potency was observed for octapeptide-length substrate analogues but inhibition progressively weakened as the molecule was shortened from the amino terminal end.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(86)90528-0