Comparison of the nucleotide sequences of diabetogenic and nondiabetogenic encephalomyocarditis virus
The nucleotide sequences of a diabetogenic variant of encephalomyocarditis (EMC) virus (D variant, ifp − phenotype) and a nondiabetogenic variant of EMC virus (B variant, ifp + phenotype) have been compared. These variants differ at eight sites. The poly(C) tract of EMC-B is three bases shorter than...
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Published in | Virology (New York, N.Y.) Vol. 166; no. 2; pp. 603 - 607 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
San Diego, CA
Elsevier Inc
01.10.1988
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The nucleotide sequences of a diabetogenic variant of encephalomyocarditis (EMC) virus (D variant, ifp
− phenotype) and a nondiabetogenic variant of EMC virus (B variant, ifp
+ phenotype) have been compared. These variants differ at eight sites. The poly(C) tract of EMC-B is three bases shorter than that of EMC-D. Of the seven sites at which nucleotide substitutions were confirmed using RNA templates, four resulted in amino acid changes in three different proteins, the leader peptide, t B (VP2), and 1D (VPI ). The biological significance of these differences can now be investigated. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0042-6822 1096-0341 |
DOI: | 10.1016/0042-6822(88)90534-X |