Cytogenetic survey of 53 Moroccan patients with acute myeloblastic leukemia

• Published in: Cancer genetics and cytogenetics Vol. 86; no. 2; pp. 124 - 128
• Main Authors: Hda, N., Chadli, B., Bousfiha, A., Trachli, A., Harif, M., Benslimane, A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.1996; Elsevier Science
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Child; Child, Preschool; Chromosome Aberrations; Female; Hematologic and hematopoietic diseases; Humans; Leukemia, Myeloid, Acute - epidemiology; Leukemia, Myeloid, Acute - genetics; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Morocco - epidemiology; Morocco; Africa; Chromosomal aberration; Human; Phenotype; Acute; Cytogenetics; Exploration; Genotype; Malignant hemopathy; Epidemiology; Age; Karyotype; Acute myelocytic leukemia
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/0165-4608(95)00188-3

We present a cytogenetic survey of chromosome aberrations for 53 Moroccan patients with acute myeloblastic leukemia (AML). Our 53 patients were 2 to 70 years old with 31 men and 22 women. The cytogenetic study was performed with the following three methods: first, relative proportion of normal (N) or abnormal (A) metaphases; second, presence of specific or random abnormalities; and third, karyotype complexity. Among 36 patients (67%) with a chromosomal abnormality, 18 (34%) showed a specific aberration. We have found t(9;22) in three patients (5%), chromosome 5 or 7 abnormality in six (11%), del(11)(q23) in three (6%), +21 in four (8%), and +8 in two (4%). Specific translocations associated with the FAB type were found: t(8;21) with AML2 in 12 patients (23%) and t(9;11) with AML5 in one (2%). Rare abnormalities were also found: one patient with t(7;21) associated with AML2 and another patient with r(1) ring associated with AML1. We concluded that our study in a Moroccan population confirmed the relation between some specific abnormalities and the FAB classification. We have found a higher incidence for t(8;21) than usually described. Finally, we have identified chromosomal abnormalities t(7;21)(q22;p11) and r(1), rarely described before.