Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against . Our study identified compounds , , , and whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.

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Bibliographic Details
Published inMedChemComm Vol. 9; no. 12; pp. 2037 - 2044
Main Authors Veale, Clinton G L, Hoppe, Heinrich C
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.12.2018
Subjects
Pathogens
Protozoa
Screening
Selectivity
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Summary:This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against . Our study identified compounds , , , and whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.
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ISSN:2040-2503
2040-2511
DOI:10.1039/c8md00319j