Inhibitory effect of whole oat on aberrant crypt foci formation and colon tumor growth in ICR and BALB/c mice

Recently, the incidence of colon cancer has been rapidly increasing in previously low-risk countries other than the Western world. Since dietary factors are thought to be key components involved in high risk colon cancer, the current trend for colon cancer prevention is toward dietary intervention....

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Published inJournal of cereal science Vol. 53; no. 1; pp. 73 - 77
Main Authors Wang, Hsueh-Chun, Hung, Chia-Hung, Hsu, Jeng-Dong, Yang, Mon-Yuan, Wang, Shing-Jung, Wang, Chau-Jong
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.01.2011
Elsevier
Subjects
Aberrant crypt foci
Biological and medical sciences
Cereal and baking product industries
Colon cancer
Food industries
Fundamental and applied biological sciences. Psychology
Whole oat
Colon cancer
Whole oat
ACF
DSS
Aberrant crypt foci
DMH
Oat
Digestive system
Growth
Gut
Cereal
Malignant tumor
Cancer
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Summary:Recently, the incidence of colon cancer has been rapidly increasing in previously low-risk countries other than the Western world. Since dietary factors are thought to be key components involved in high risk colon cancer, the current trend for colon cancer prevention is toward dietary intervention. To explore if whole oat functions as a chemoprevention agent, an inflammation-related mouse colon cancer model, initiated with 1, 2-dimethylhydrazine (DMH), followed by dextran sodium sulfate (DSS), was performed to evaluate the preventive effect of whole oat containing diets. The result indicated middle and high dose whole oat diets significantly reduced the number of aberrant crypt foci (ACF) as well as colon tumors. Further, human colon carcinoma cells were subcutaneously inoculated into BALB/cAnNg-Foxn1 nude mice to measure the growth inhibition on whole oat diets. Low, middle and high dose whole oat diets significantly decreased the tumor volumes by 13%, 17% and 43%, respectively, indicating a dose dependent inhibitory effect. Meanwhile, 38% and 54% reductions in tumor weights were observed in middle and high dose whole oat diets. Together, the evidence suggests whole oat helps protect against colon cancer development and could be a good chemoprevention agent taken as a daily supplement.
Bibliography:http://dx.doi.org/10.1016/j.jcs.2010.09.009
ISSN:0733-5210
1095-9963
DOI:10.1016/j.jcs.2010.09.009