Lymphocyte sub-populations in human cord blood: analysis with monoclonal antibodies

Lymphocytes and monocytes in human cord blood have been analysed using a panel of fourteen monoclonal antibodies. Contrary to earlier data based on the sheep erythrocyte rosette assay for T cells, no marked deficit in T cells was found in cord as compared with adult blood. The T cells in cord blood...

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Bibliographic Details
Published inJournal of reproductive immunology Vol. 5; no. 5; pp. 311 - 317
Main Authors Zola, H., Moore, H.A., Bradley, J., Need, J.A., Beverley, P.C.L.
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 01.01.1983
Elsevier Science
Subjects
Antibodies, Monoclonal - immunology
Antigens, Surface - analysis
Biological and medical sciences
Fetal Blood - cytology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
General aspects. Ontogeny. Phylogeny
Humans
Immunobiology
Lymphocytes - classification
Lymphocytes - immunology
Immunological investigation
T-Lymphocyte
B-Lymphocyte
Monoclonal antibody
Umbilical cord
New born
Lymphocyte
Cell subpopulation
Blood
Immunological method
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Summary:Lymphocytes and monocytes in human cord blood have been analysed using a panel of fourteen monoclonal antibodies. Contrary to earlier data based on the sheep erythrocyte rosette assay for T cells, no marked deficit in T cells was found in cord as compared with adult blood. The T cells in cord blood had a relatively immature phenotype whereas B cells showed a mature phenotype. The phenotypic differences between adult and cord blood appear minor in relation to the marked functional differences reported by others.
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ISSN:0165-0378
1872-7603
DOI:10.1016/0165-0378(83)90257-7