Cytogenetic findings in a case of nodular fasciitis of the breast

• Published in: Cancer genetics and cytogenetics Vol. 81; no. 2; pp. 166 - 168
• Main Authors: Birdsall, Sandra H., Shipley, Janet M., Summersgill, Brenda M., Black, Andy J.M., Jackson, P., Kissin, Mark W., Gusterson, Barry A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.1995; Elsevier Science
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; breast; Breast Diseases - genetics; cell proliferation; Chromosome 15; Chromosome Aberrations; cytogenetics; Fasciitis - genetics; Gynecology. Andrology. Obstetrics; Humans; Karyotyping; Mammary gland diseases; man; Medical sciences; nodular fasciitis; translocation; Tumors; Human; Connective tissue disease; Skin disease; Nodular fasciitis; Exploration; Case study; Mammary gland diseases; Cytogenetics; Genetics; Female; Mammary gland; Benign neoplasm; Elderly
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/0165-4608(94)00229-5

We report the cytogenetic findings in a case of nodular fasciitis of the breast. The abnormalities found in all 11 metaphases available for analysis were −2, −2, −1,der(15)t(2;15)(q31;q26), +der(?) t(?;2), +mar1, +mar2. Other consistent abnormalities were also identified. Fluorescence in situ hybridization (FISH) was used to confirm the origin of some of the chromosomes. A large acrocentric chromosome was confirmed to be derived from chromosome 15 with chromosome 2 material translocated onto the q arm. The metacentric der(?)t(?;2) was demonstrated to have part of chromosome 2 on the q arm. No other chromosome 2 material was found. Eight of 11 cells were tetraploid and had two copies of a del(6)(q16q24).