Major antigenic groups of rabies virus in canada determined by anti-nucleocapsid monoclonal antibodies

• Published in: Comparative immunology, microbiology and infectious diseases Vol. 9; no. 1; pp. 59 - 69
• Main Authors: Webster, W.A., Casey, G.A., Charlton, K.M.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1986; Elsevier
• Subjects: Animals; Animals, Domestic; Animals, Wild; Antibodies, Monoclonal; anticorps monoclonaux; Antigens, Viral - analysis; Biological and medical sciences; Canada; Capsid - analysis; Cats; Demography; Dogs; Epidemiology; field virus; Foxes; Fundamental and applied biological sciences. Psychology; Groupes du virus rabique; Horses; Mammalia; Mephitidae; Microbiology; monoclonal antibodies; Rabies - veterinary; Rabies groups; rabies virus; Rabies virus - isolation & purification; Rats; Viral Core Proteins - analysis; Virology; virus de la rue; Canada; field virus; Canada; Groupes du virus rabique; virus de la rue; anticorps monoclonaux; Rabies groups; monoclonal antibodies; Antigenic determinant; Monoclonal antibody; North America; Epidemiology; Rhabdoviridae; America; Horse; Chiroptera; Ungulata; Eptesicus fuscus; Rodentia; Rabies virus; Strain; Infection; Virus; Vertebrata; Mammalia; Myotis lucifugus; Nucleocapside; Viral disease; Animal; Rabies; Lyssavirus; Perissodactyla
• ISSN: 0147-9571; 1878-1667
• DOI: 10.1016/0147-9571(86)90076-7

A total of 123 rabies virus isolates from various geographical areas in Canada were characterized by a panel of 43 anti-nucleocapsid monoclonal antibodies. Four major antigenic groups are found in terrestrial mammals: “Canadian Arctic” from Ontario, Quebec and the Northwest Territories; “south-eastern Georgian Bay” from Ontario; “south mid-central skunk” from Alberta, Saskatchewan and Manitoba; and “Brook's, Alberta skunk” from a restricted area in Alberta. Bat isolates can be divided into 4 major antigenic groups: “B-1” in Eptesicus fuscus from Ontario; “B-2” in a variety of bat species from British Columbia eastward into Ontario; “B-3” in Myotis spp. from Ontario and New Brunswick; and “B-4” in E. fuscus from Alberta and Saskatchewan. A single case of bat to horse transmission of rabies virus is recorded. These street isolates are compared with isolates of fixed virus. Epidemiological aspects are discussed. Une batterie de 43 anticorps monoclonaux dirigés contre les déterminants antigéniques des protéines de la nucléocapside ont été utilisée pour l'examen de 123 souches de virus rabique au Canada. Il y a 4 groupes majeurs de virus rabique dans les mammifères terrestres: “Canadian Arctic” de plusieurs espèces de l'Ontario, du Quebec et des Terretoires du Nord; “south-eastern Georgian Bay” qui existe dans un région restreinte de l'Ontario; “south mid-central skunk” du Manitoba, de la Saskatchewan et de l'Alberta; et “Brook's, Alberta skunk” des mouffettes près de Brooks, Alberta. Les groupes majeurs des chauves-souris sont dévisé en 4: “B-1” en Eptesicus fuscus de l'Ontario; “B-2” en plusieurs espèces de la Colombie Britanique, de l'Alberta, de la Saskatchewan, du Manitoba et de l'Ontario; “B-3” en Myotis de l'Ontario et du Nouveau Brunswick; et “B-4” en Eptesicus de l'Alberta et de la Saskatchewan. Il y a un cas d'infection d'un cheval par une chauve-souris en Colombie Britanique.