Alterations in CNS amine levels by acclimatization to hypobaric hypoxia

Rabbits were acclimatized to simulated high altitude (SHA) (hypobaric hypoxia) at 6000 M (350 torr) on alternate days for 70 days. The norepinephrine levels of the midbrain were lower in the acclimatized animal compared to the controls (p less than 0.06) and 3,4 dihydroxyphenylacetic acid (DOPAC) wa...

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Bibliographic Details
Published inBrain research bulletin Vol. 11; no. 2; p. 255
Main Authors Hughes, M J, Light, K E, Redington, T
Format Journal Article
LanguageEnglish
Published United States 01.01.1983
Subjects
3,4-Dihydroxyphenylacetic Acid - analysis
Acclimatization
Altitude
Animals
Biogenic Amines - analysis
Brain Chemistry
Dopamine - analysis
Female
Hypoxia - metabolism
Methoxyhydroxyphenylglycol - analogs & derivatives
Methoxyhydroxyphenylglycol - analysis
Norepinephrine - analysis
Rabbits
Rats
Rats, Inbred Strains
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Summary:Rabbits were acclimatized to simulated high altitude (SHA) (hypobaric hypoxia) at 6000 M (350 torr) on alternate days for 70 days. The norepinephrine levels of the midbrain were lower in the acclimatized animal compared to the controls (p less than 0.06) and 3,4 dihydroxyphenylacetic acid (DOPAC) was significantly higher (p less than 0.04) in the striatum of control than in the test animals. The mean dopamine (DA) levels in the striatum of the test animals were higher than the controls. The ratio of DOPAC/DA was 2.0 for the controls and 0.4 for the SHA brains which suggests reduced dopamine turnover in the striatum of the SHA rabbits. Rats acclimatized in the same manner did not show any difference in the NE or DA levels between the control and SHA animals, possibly the result of species differences.
ISSN:0361-9230
DOI:10.1016/0361-9230(83)90200-9