Evaluation for roles of periventricular cholinoceptors in vasopressin secretion in response to angiotensin II and an osmotic stimulus

In conscious rats, intracerebroventricular (i.c.v.) injections (10 microliters) of carbachol (1.4 nmol), angiotensin II (AII; 48.2 pmol) or a hypertonic solution (990 mOsm/kg) produced increases of plasma vasopressin (AVP) and arterial pressure. The effects of carbachol were inhibited not by a nicot...

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Bibliographic Details
Published inBrain research Vol. 496; no. 1-2; p. 345
Main Authors Yamaguchi, K, Hama, H
Format Journal Article
LanguageEnglish
Published Netherlands 04.09.1989
Subjects
Angiotensin II - pharmacology
Animals
Blood Pressure - drug effects
Carbachol - pharmacology
Cerebral Ventricles - drug effects
Cerebral Ventricles - metabolism
Heart Rate - drug effects
Male
Osmolar Concentration
Rats
Rats, Inbred Strains
Receptors, Cholinergic - drug effects
Receptors, Cholinergic - physiology
Vasopressins - blood
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Summary:In conscious rats, intracerebroventricular (i.c.v.) injections (10 microliters) of carbachol (1.4 nmol), angiotensin II (AII; 48.2 pmol) or a hypertonic solution (990 mOsm/kg) produced increases of plasma vasopressin (AVP) and arterial pressure. The effects of carbachol were inhibited not by a nicotinic cholinergic blocker hexamethonium (28 nmol), but by a muscarinic cholinergic blocker atropine (28 nmol). However, neither hexamethonium nor atropine affected the AVP and pressor responses to AII or the hypertonic solution. We concluded that periventricular cholinoceptors may not be involved in the central actions of AII and hypertonicity on AVP release and blood pressure.
ISSN:0006-8993
DOI:10.1016/0006-8993(89)91086-X