Gonadotropin-Releasing Hormone (GnRH) and Its Agonists in Bovine Reproduction I: Structure, Biosynthesis, Physiological Effects, and Its Role in Estrous Synchronization

• Published in: Animals (Basel) Vol. 14; no. 10; p. 1473
• Main Authors: Hassanein, Eman M, Szelényi, Zoltán, Szenci, Ottó
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Amino acids; Biosynthesis; Dairy cattle; Enzymes; estrous synchronization; Feedback; Fertility; Follicle-stimulating hormone; follicular dynamic; Gene expression; Glycoproteins; GnRH analog; gonadotropins; hypothalamic–pituitary axis; Hypothalamus; Kinases; Livestock; Luteinizing hormone; Nafarelin; Neuropeptides; Ovaries; Ovulation; Peptides; Physiological aspects; Physiology; Pituitary gland; Product introduction; Proteins; reproductive performance; Steroids; dairy cattle; follicular dynamic; GnRH analog; estrous synchronization; reproductive performance; gonadotropins; hypothalamic–pituitary axis
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani14101473

GnRH is essential for the regulation of mammalian reproductive processes. It regulates the production and release of pituitary gonadotropins, thereby influencing steroidogenesis and gametogenesis. While primarily produced in the hypothalamus, GnRH is also produced in peripheral organs, such as the gonads and placenta. GnRH analogs, including agonists and antagonists, have been synthesized for the reproductive management of animals and humans. This review focuses on the functions of hypothalamic GnRH in the reproductive processes of cattle. In addition to inducing the surge release of LH, the pulsatile secretion of GnRH stimulates the pituitary gland to release FSH and LH, thereby regulating gonadal function. Various GnRH-based products have been synthesized to increase their potency and efficacy in regulating reproductive functions. This review article describes the chemical structures of GnRH and its agonists. This discussion extends to the gene expression of GnRH in the hypothalamus, highlighting its pivotal role in regulating the reproductive process. Furthermore, GnRH is involved in regulating ovarian follicular development and luteal phase support, and estrus synchronization is involved. A comprehensive understanding of the role of GnRH and its analogs in the modulation of reproductive processes is essential for optimizing animal reproduction.