Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery

Light-driven inward proton pump rhodopsin Rm XeR was embedded in pH-sensitive liposomes. Substance release from the proteoliposomes was observed following light illumination both in vitro and in cells, indicating the successful production of light-induced disruptive liposomes (LiDL). Thus, LiDL is a...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 49; pp. 7591 - 7594
Main Authors Tsuneishi, Taichi, Kojima, Keiichi, Kubota, Fumika, Harashima, Hideyoshi, Yamada, Yuma, Sudo, Yuki
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 15.06.2023
Subjects
Excipients
Hydrogen-Ion Concentration
Ion Transport
Light
Liposomes
Rhodopsin - metabolism
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Summary:Light-driven inward proton pump rhodopsin Rm XeR was embedded in pH-sensitive liposomes. Substance release from the proteoliposomes was observed following light illumination both in vitro and in cells, indicating the successful production of light-induced disruptive liposomes (LiDL). Thus, LiDL is a photoswitchable carrier utilized for intracellular substance delivery. We developed here light-induced disruptive liposomes (LiDL) using both inward proton pump rhodopsin Rm XeR and pH-sensitive liposomes. Then we demonstrated that LiDL works as a photoswitchable carrier for intracellular substance delivery.
Bibliography:https://doi.org/10.1039/d3cc02056h
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc02056h