The effects goat milk yoghurt casein on malondialdehyde (MDA) level of rats (Rattus norvegicus) exposured by 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCCD)

Dioxins are a group of compounds that are poisonous (toxic) and it was a factor to trigger cancer (carcinogenic substance). The most toxic dioxin was 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Dioxins can cause health problems due to the nature of persistent and can bioaccumulate in the fat body. C...

Full description

Saved in:
Bibliographic Details
Published inIOP conference series. Materials Science and Engineering Vol. 509; no. 1; pp. 12026 - 12030
Main Authors Mahdi, Chanif, Haskito Ajeng, Maya Erika Prihastuti, Sari, Melinda Puspita
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 03.05.2019
Subjects
Antioxidants
Bioaccumulation
Carcinogens
Casein
Casein goat milk yogurt
Confidence intervals
Dioxins
Exposure
Goats
Heart
Malondialdehyde
MDA
Milk
Rats
Spectrophotometry
Thiobarbituric acid
Variance analysis
Yogurt
Online AccessGet full text

Cover

More Information
Summary:Dioxins are a group of compounds that are poisonous (toxic) and it was a factor to trigger cancer (carcinogenic substance). The most toxic dioxin was 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Dioxins can cause health problems due to the nature of persistent and can bioaccumulate in the fat body. Casein goat milk yogurt potential as an antioxidant. This study aimed was to determine the effect of goat milk yogurt to dioxin exposure were observed in the levels of Malondialdehyde (MDA) of heart rats (Rattus norvegicus). Itwas an experimental study by used a completely randomized design (CRD). The rats (Rattus norvegicus) were divided into 6 groups, the each namely were: the negative control group (K-), control casein group (KK), the positive control group (K+), treatment 1 group (K1), treatment 2 group (K2), and treatment 3 group (K3). Heart MDA levels measured by used thiobarbituric acid (TBA) with UV-Vis spectrophotometry method at a wavelength of 530 nm. MDA heart analysed by one-way Analysis of Variance (ANOVA) confidence level α = 5%. The results showed that the best yogurt casein dose used to inhibit MDA in TCDD-rats is 900 mg/kg. Casein goat milk yogurt can prevent the increase of MDA significantly (p<0.01) as a result of exposure to TCDD. Goat's milk yogurt casein dose of 900 mg/kg is the best dose. The conclusion is the provision casein goat milk yogurt can prevent the increase of MDA caused by exposure to TCDD.
ISSN:1757-8981
1757-899X
1757-899X
DOI:10.1088/1757-899X/509/1/012026