Antibody escape kinetics of equine infectious anemia virus infection of horses

Lentivirus escape from neutralizing antibodies (NAbs) is not well understood. In this work, we quantified antibody escape of a lentivirus, using antibody escape data from horses infected with equine infectious anemia virus. We calculated antibody blocking rates of wild-type virus, fitness costs of m...

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Bibliographic Details
Published inJournal of virology Vol. 89; no. 13; pp. 6945 - 6951
Main Authors Schwartz, Elissa J, Nanda, Seema, Mealey, Robert H
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.07.2015
Subjects
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Equine Infectious Anemia - immunology
Equine Infectious Anemia - virology
Equine infectious anemia virus
Horses
Immune Evasion
Infectious Anemia Virus, Equine - genetics
Infectious Anemia Virus, Equine - growth & development
Infectious Anemia Virus, Equine - immunology
Lentivirus
Models, Theoretical
Mutation
Pathogenesis and Immunity
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Summary:Lentivirus escape from neutralizing antibodies (NAbs) is not well understood. In this work, we quantified antibody escape of a lentivirus, using antibody escape data from horses infected with equine infectious anemia virus. We calculated antibody blocking rates of wild-type virus, fitness costs of mutant virus, and growth rates of both viruses. These quantitative kinetic estimates of antibody escape are important for understanding lentiviral control by antibody neutralization and in developing NAb-eliciting vaccine strategies.
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E.J.S. and S.N. contributed equally to this work.
Citation Schwartz EJ, Nanda S, Mealey RH. 2015. Antibody escape kinetics of equine infectious anemia virus infection of horses. J Virol 89:6945–6951. doi:10.1128/JVI.00137-15.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00137-15