Towards homochiral supramolecular entities from achiral molecules by vortex mixing-accompanied self-assembly

• Published in: Chemical science (Cambridge) Vol. 10; no. 9; pp. 2718 - 2724
• Main Authors: Sang, Yutao, Yang, Dong, Duan, Pengfei, Liu, Minghua
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 07.03.2019
• Subjects: Additives; Assemblies; Chirality; Gelation; Gels; Handedness; Nucleation; Ripening; Seeds; Self-assembly; Supramolecular compounds; Unity; Vortices
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/c8sc04687e

Achieving homochirality is challenging both at the molecular and the supramolecular levels. While the origin of molecular homochirality still remains mysterious, the fabrication of homochiral assemblies from achiral molecules has attracted considerable interest since it provides many clues to understand the origin of molecular chirality. Here, by using a vortex mixing-accompanied self-assembly strategy, we obtained near-unity homochiral entities with controlled handedness from supramolecular gels that consist of exclusively achiral molecules without any chiral additives. The common supramolecular gelation process heating and cooling of the achiral molecules only resulted in racemic gels. However, if vortex mixing is applied during the self-assembly, near-unity homochiral assemblies with uncontrolled handedness were obtained. Vortex mixing during the nucleation stage was found to be crucial in this case. On the other hand, if a small amount of the above vortex mixing produced assemblies was added as chiral seeds into the racemic gels, the racemic gels turned into near-unity homochiral suspensions with controlled handedness a ripening process. Our studies provide an intriguing approach for achieving homochiral supramolecular assemblies from achiral molecules.