Lactobacillus paragasseri OLL2809 Improves Premenstrual Psychological Symptoms in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Study

• Published in: Nutrients Vol. 15; no. 23; p. 4985
• Main Authors: Sato, Asako, Fukawa-Nagira, Akika, Sashihara, Toshihiro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2023
• Subjects: Analgesics; arousal; Cancer therapies; Cellulose; Clinical trials; Endometriosis; Herbal medicine; irritability; Lactobacillus paragasseri OLL2809; MDQ; Menstruation; Microbiota; Ovarian cancer; Pain; PMS; premenstrual symptoms; Premenstrual syndrome; probiotics; Questionnaires; Review boards; Womens health; Japan; hypothalamic-pituitary-adrenal axis; premenstrual symptoms; irritability; activity; Lactobacillus paragasseri OLL2809; MDQ; arousal; probiotics
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15234985

OLL2809 has been shown to ameliorate stress. This study employed a randomized, placebo-controlled, double-blind, parallel-group design to assess the efficacy of continuous ingestion of OLL2809 for managing menstrual symptoms in healthy women. Eighty healthy adult women aged 25-40 years who experienced premenstrual and menstrual symptoms were randomly assigned to either the OLL2809 or placebo group ( = 40 each) and ingested tablets containing OLL2809 or placebo for three menstrual cycles. The OLL2809 group exhibited a significantly greater change in premenstrual 'arousal' scores on the menstrual distress questionnaire compared to the placebo group after the three menstrual cycles. Specifically, changes in the 'activity' subfactor were significantly higher in the OLL2809 group than in the placebo group. Additionally, the OLL2809 group reported significantly lower premenstrual irritability on the visual analog scale than the placebo group. These results suggest that OLL2809 may contribute to enhancing the quality of life of women.