Soluble P-selectin as a marker of in vivo platelet activation
Platelets are the major source of circulating sP-selectin. Elevated levels of this protein have been found in many atherothrombotic disorders. Thus, we investigated whether sP-selectin dosage might reflect platelet function in patients with risk factors for or with established cardiovascular disease...
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Published in | Clinica chimica acta Vol. 399; no. 1; pp. 88 - 91 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
2009
|
Subjects | |
Online Access | Get full text |
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Summary: | Platelets are the major source of circulating sP-selectin. Elevated levels of this protein have been found in many atherothrombotic disorders. Thus, we investigated whether sP-selectin dosage might reflect platelet function in patients with risk factors for or with established cardiovascular diseases and whether its levels can be modulated by aspirin therapy.
Plasma sP-selectin levels and light transmission platelet aggregometry (LTA) were analyzed in 152 outpatients. The effects of a 6-month aspirin therapeutic course on sP-selectin levels and LTA in 51 consecutive patients have been also investigated.
Significant correlations were observed between sP-selectin and Mx% LTA in response to epinephrine (
p
=
0.022) and arachidonic acid (
p
=
0.006), or between sP-selectin and collagen lag-phase (
p
=
0.016). Multiple regression analysis showed that the only predictors of sP-selectin levels were platelet number (
p
<
0.001) and collagen-induced lag-phase (
p
<
0.01). Aspirin-treated patients showed a significant reduction of sP-selectin levels by 13% (
p
=
0.021) which significantly correlated with collagen-induced lag-phase (
p
=
0.005).
sP-selectin dosage could be proposed as a reliable marker of platelet activation in patients with major atherosclerotic risk factors either in the absence of clinically overt disease, and might represent a valid tool to asses in vivo platelet behavior. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0009-8981 1873-3492 |
DOI: | 10.1016/j.cca.2008.09.018 |