Design and an efficient synthesis of new thiorotenone derivatives

• Published in: Bioorganic & medicinal chemistry letters Vol. 20; no. 9; pp. 2884 - 2887
• Main Authors: Yao, Changsheng, Wang, Cuihua, Jiang, Bei, Feng, Xiaodong, Yu, Chenxia, Li, Tuanjie, Tu, Shujiang
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.05.2010; Elsevier
• Subjects: Biomedical screening; Chemistry; Crystallography, X-Ray; Drug Design; Exact sciences and technology; Heterocyclic compounds; Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives; Molecular Conformation; Multicomponent reaction; Organic chemistry; Preparations and properties; Rotenone - chemical synthesis; Rotenone - chemistry; Rotenone - pharmacology; Solvent-free synthesis; Thiopyrano[3,4- b]pyran; Multicomponent reaction; Biomedical screening; Thiopyrano[3,4- b]pyran; Solvent-free synthesis; Oxygen sulfur heterocycle; Nitrile; Arenal; Molecular structure; Benzene derivatives; Lactone; Ketone; X ray diffraction; Solvent free; Bicyclic compound; Malononitrile; Thiopyrano[3,4-6]pyran; Chemical synthesis; Halogen Organic compounds; Crystalline structure
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2010.03.036

A series of novel 4-aryl-thiopyrano[3,4- b]pyran-5-one derivatives were synthesized through an efficient one-pot three-component reaction under solvent-free conditions. This work provides a new series of derivatives of thiorotenone with potential anticancer activity for biomedical screening. A series of novel 4-aryl-thiopyrano[3,4- b]pyran-5-one derivatives were synthesized through an efficient one-pot three-component reaction under solvent-free conditions. This work provides a new series of derivatives of thiorotenone with potential biological activity for biomedical screening.