Hippocampal long-term potentiation increases mitochondrial calcium pump activity in rat

45Ca2+ pump activity was measured in hippocampal homogenates after the induction of long-term potentiation (LTP) of perforant path-dentate gyrus synapses in vivo. The mitochondrial poison, sodium azide, was used to separate mitochondrial from non-mitochondrial 45Ca2+ uptake. High-frequency stimulati...

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Bibliographic Details
Published inBrain research Vol. 382; no. 1; p. 185
Main Authors Stanton, P K, Schanne, F A
Format Journal Article
LanguageEnglish
Published Netherlands 10.09.1986
Subjects
Animals
Calcium - metabolism
Calcium-Transporting ATPases - metabolism
Electric Stimulation
Evoked Potentials
Hippocampus - drug effects
Hippocampus - physiology
Kinetics
Male
Mitochondria - drug effects
Mitochondria - metabolism
Rats
Rats, Inbred Strains
Synapses - physiology
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Summary:45Ca2+ pump activity was measured in hippocampal homogenates after the induction of long-term potentiation (LTP) of perforant path-dentate gyrus synapses in vivo. The mitochondrial poison, sodium azide, was used to separate mitochondrial from non-mitochondrial 45Ca2+ uptake. High-frequency stimulation of the perforant path input produced a selectively increased mitochondrial uptake of calcium. This increased pump activity may permit granule cells to more effectively buffer higher intracellular calcium levels associated with LTP.
ISSN:0006-8993
DOI:10.1016/0006-8993(86)90130-7