Glycine potentiates NMDA responses in rat hippocampal CA1 neurons

When superfused onto rat hippocampal slices, glycine (0.1-0.5 mM) potentiated the depolarization induced by pressure application of NMDA in normal Krebs solution and the synaptic discharge evoked by stimulation of the Schaffer collateral-commissural inputs to the CA1 pyramidal neurons bathed in Mg2+...

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Bibliographic Details
Published inNeuroscience letters Vol. 100; no. 1-3; p. 237
Main Authors Minota, S, Miyazaki, T, Wang, M Y, Read, H L, Dun, N J
Format Journal Article
LanguageEnglish
Published Ireland 22.05.1989
Subjects
2-Amino-5-phosphonovalerate
Action Potentials - drug effects
Animals
Aspartic Acid - analogs & derivatives
Aspartic Acid - pharmacology
Glycine - pharmacology
Hippocampus - drug effects
Hippocampus - physiology
Humans
N-Methylaspartate
Rats
Valine - analogs & derivatives
Valine - pharmacology
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Summary:When superfused onto rat hippocampal slices, glycine (0.1-0.5 mM) potentiated the depolarization induced by pressure application of NMDA in normal Krebs solution and the synaptic discharge evoked by stimulation of the Schaffer collateral-commissural inputs to the CA1 pyramidal neurons bathed in Mg2+-free media; the effects were not prevented by strychnine. In addition, glycine partially reversed the blocking effect of D-2-amino-5-phosphonovalerate (AP5) on N-methyl-D-aspartate (NMDA)-induced depolarization. These results show that glycine at relatively high concentrations potentiates the NMDA-mediated response in hippocampal slices.
ISSN:0304-3940
DOI:10.1016/0304-3940(89)90691-5