Microinjections of GABA agonists into the amygdala complex attenuates kindled seizure expression in the rat

• Published in: Experimental neurology Vol. 102; no. 2; pp. 185 - 189
• Main Authors: Applegate, Craig D., Burchfiel, James L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.11.1988; Elsevier
• Subjects: Aminocaproates - pharmacology; Amygdala - physiology; Animals; Behavior, Animal - drug effects; Biological and medical sciences; Cerebral Cortex - physiology; gamma-Aminobutyric Acid - physiology; Kindling, Neurologic; Limbic System - physiology; Male; Medical sciences; Microinjections; Muscimol - pharmacology; Nervous system involvement in other diseases. Miscellaneous; Neurology; Rats; Rats, Inbred Strains; Seizures - etiology; Seizures - physiopathology; Vigabatrin; Nervous system diseases; Amygdala; Pathophysiology; Rat; Epilepsy; Gabaergic agonist; Rodentia; Exploration; Electroencephalography; Electrodiagnosis; Vertebrata; Experimental disease; Mammalia; Animal; Intracerebral administration; Biological effect
• ISSN: 0014-4886; 1090-2430
• DOI: 10.1016/0014-4886(88)90092-1

The effects of intraamygdala injections of either γ-vinyl GABA or muscimol on the behavioral and electrographic expression of stable, fully generalized, kindled seizures were assessed. Results suggest that intraamygdala administration of GABA agonists preferentially attenuates the behavioral, but not the focal, electrographic expression of kindled seizures elicited from either the insular or entorhinal cortex. These results, in conjunction with those of others, suggest that the amygdala becomes an integral and necessary structure for the expression of seizures kindled from a variety of forebrain areas.