The cholinergic system participates in thyrotropin-releasing hormone (TRH) regulation

The effect of chronic atropine treatment was studied on thyrotropin releasing hormone (TRH) content of several brain areas in Wistar rats. Atropine produced TRH increases in the septal area, preoptic area and the hypophysis; this was observed when rats were killed immediately after the last dose, wh...

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Published inNeuroscience letters Vol. 135; no. 2; p. 193
Main Authors Garcia, S I, Pirola, C J, Dabsys, S M, Santajuliana, D, Delorenzi, A, Finkielman, S, Nahmod, V E
Format Journal Article
LanguageEnglish
Published Ireland 03.02.1992
Subjects
Animals
Atropine - pharmacology
Brain Chemistry - drug effects
Male
Nerve Tissue Proteins - metabolism
Parasympathetic Nervous System - drug effects
Parasympathetic Nervous System - physiology
Radioimmunoassay
Rats
Rats, Inbred Strains
Thyrotropin-Releasing Hormone - cerebrospinal fluid
Thyrotropin-Releasing Hormone - metabolism
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Summary:The effect of chronic atropine treatment was studied on thyrotropin releasing hormone (TRH) content of several brain areas in Wistar rats. Atropine produced TRH increases in the septal area, preoptic area and the hypophysis; this was observed when rats were killed immediately after the last dose, while a decrease was observed only in the hypophysis 48 h after the last atropine dose. TRH concentration in cerebrospinal fluid rose significantly after atropine withdrawal with respect to controls. Treatment with eserine, an acetylcholinesterase inhibitor, produced the same effect. These results indicate cholinergic participation in central TRH regulation.
ISSN:0304-3940
DOI:10.1016/0304-3940(92)90434-9