Phantom Model of Physiologic Intracranial Pressure and Cerebrospinal Fluid Dynamics

• Published in: IEEE transactions on biomedical engineering Vol. 59; no. 6; pp. 1532 - 1538
• Main Authors: Bottan, Simone, Poulikakos, Dimos, Kurtcuoglu, Vartan
• Format: Journal Article
• Language: English
• Published: New York, NY IEEE 01.06.2012; Institute of Electrical and Electronics Engineers
• Subjects: Anatomical model; Biological and medical sciences; Biomedical monitoring; Biomimetic Materials; Brain - anatomy & histology; Brain - physiology; Brain modeling; Cerebrospinal Fluid - physiology; compliance; Cranial; Equipment Design; Equipment Failure Analysis; Fundamental and applied biological sciences. Psychology; General aspects. Models. Methods; Humans; In vivo; Intracranial Pressure - physiology; Iterative closest point algorithm; Magnetic Resonance Imaging - methods; Phantoms; Phantoms, Imaging; subarachnoid space (SAS); Synthetic aperture sonar; ventricular system; Vertebrates: nervous system and sense organs; Fluid dynamics; Cerebral ventricle; Cerebrospinal fluid; Intracranial pressure; subarachnoid space (SAS); Anatomy; Modeling; Anatomical model; Subarachnoidal space; compliance; ventricular system; Biomedical engineering; Test object
• ISSN: 0018-9294; 1558-2531; 1558-2531
• DOI: 10.1109/TBME.2012.2187448

We describe herein a novel life-size phantom model of the intracranial cavity and its validation. The cerebrospinal fluid (CSF) domains including ventricular, cysternal, and subarachnoid spaces were derived via magnetic resonance imaging. Brain mechanical properties and cranio-spinal compliance were set based on published data. Both bulk and pulsatile physiologic CSF flow were modeled. Model validation was carried out by comparisons of flow and pressure measurements in the phantom with published in vivo data of healthy subjects. Physiologic intracranial pressure with 10 mmHg mean and 0.4 mmHg peak pulse amplitude was recorded in the ventricles. Peak CSF flow rates of 0.2 and 2 ml/s were measured in the cerebral aqueduct and subarachnoid space, respectively. The phantom constitutes a first-of-its-kind approach to modeling physiologic intracranial dynamics in vitro. Herein, we describe the phantom design and manufacturing, definition and implementation of its operating parameters, as well as the validation of the modeled dynamics.