Quantification of hepatitis B vaccine-induced antibodies as a predictor of anti-HBs persistence

• Published in: Vaccine Vol. 13; no. 5; pp. 443 - 447
• Main Authors: Gesemann, Michael, Scheiermann, Norbert
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1995; Elsevier
• Subjects: Adult; anti-HBs titres; antibody kinetics; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Hepatitis B Antibodies - biosynthesis; Hepatitis B Antibodies - blood; Hepatitis B vaccine; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - pharmacokinetics; Hepatitis B Vaccines - pharmacology; hepatitis B virus; Humans; Immunization Schedule; Immunization, Secondary; Mathematical Computing; Microbiology; Models, Biological; Predictive Value of Tests; Prospective Studies; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Virology; antibody kinetics; Hepatitis B vaccine; anti-HBs titres; Virus; Human; Immunoprotection; Immune response; Hepatitis B surface antigen; Hepadnaviridae; Antibody; Vaccine; Hepatitis B virus; Humoral immunity; Quantitative analysis
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/0264-410X(94)00010-K

Hepatitis B vaccine-induced antibodies (anti-HBs) were quantified in 35 subjects (study group) and in an additional 24–59 subjects (controls) during a period of 82 months after vaccination against hepatitis B and the values used as a basis to develop a logarithmic formula to describe the post-booster antibody kinetics. The actual anti-HBs titres are shown to be proportional to the peak titre one month post-booster but inversely proportional to the number of months between the time of booster and of retesting. Using this model and an anti-HBs quantification more than a month post-booster, the individual persistence of vaccine-induced anti-HBs antibodies can be calculated.