The effect of cholecystokinin on food intake in gonadectomized and intact rats: the influence of sex hormones

Cholecystokinin (CCK) suppresses food intake in a number of animal models, but appears to be less effective in females [5,23]. We studied the effect of CCK on food intake in female rats on each day of the estrous cycle. In addition, we evaluated the effect of sex hormones on food intake in intact an...

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Bibliographic Details
Published inPhysiology & behavior Vol. 40; no. 1; p. 25
Main Authors Wager-Srdar, S A, Gannon, M, Levine, A S
Format Journal Article
LanguageEnglish
Published United States 1987
Subjects
Animals
Castration
Circadian Rhythm
Dose-Response Relationship, Drug
Estradiol - pharmacology
Estrus - physiology
Feeding Behavior - drug effects
Female
Male
Progesterone - pharmacology
Rats
Rats, Inbred Strains
Sincalide - pharmacology
Testosterone - pharmacology
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Summary:Cholecystokinin (CCK) suppresses food intake in a number of animal models, but appears to be less effective in females [5,23]. We studied the effect of CCK on food intake in female rats on each day of the estrous cycle. In addition, we evaluated the effect of sex hormones on food intake in intact and castrate male rats which had been injected daily with oil or testosterone propionate + oil and ovariectomized female rats injected daily with oil, estradiol, progesterone or estradiol + progesterone. Food intake in intact, castrate and castrate + testosterone replaced male rats was decreased by CCK (5, 10 and 20 micrograms/kg) IP (p less than 0.05). Food intake was decreased by CCK (20 micrograms/kg) only during diestrous and metestrus in cycling female rats. During metestrus, a period of low estradiol in the presence of progesterone, food intake was also suppressed by CCK (5 and 10 micrograms/kg). CCK failed to decrease food intake in ovariectomized females receiving oil, estradiol and estradiol + progesterone. However, animals receiving progesterone alone responded to the high dose of CCK (20 micrograms/kg). Our data suggest that the effect of CCK on food intake in female rats may be dependent on the presence of progesterone. The lack of sensitivity to CCK during proestrus and estrus suggests that estradiol may be modulating the "permissive" action of progesterone on CCK's satiety effect.
ISSN:0031-9384
DOI:10.1016/0031-9384(87)90180-6