The association between vitamin E intake and remnant cholesterol, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in US adults: a cross-sectional study

• Published in: Lipids in health and disease Vol. 23; no. 1; pp. 325 - 9
• Main Authors: Wang, Yuxuan, Li, Hao, Zhang, Zhihao, Wu, Futong, Liu, Jiarui, Zhu, Zhongze, Xiang, Hongfei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.10.2024; BioMed Central; BMC
• Subjects: Adult; Adults; Analysis; Blood cholesterol; Cardiovascular diseases; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Control; Cross-Sectional Studies; Diet; Female; Health aspects; Health surveys; Humans; Linear Models; Low density lipoproteins; Male; Middle Aged; Nutrition Surveys; Physiological aspects; Prevention; Surveys; Triglycerides - blood; United States - epidemiology; Vitamin E; Vitamin E - administration & dosage; Vitamin E - blood; United States
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-024-02313-8

Blood lipid profiles are associated with various nutritional elements and dietary factors. This study aimed to explore the association between total dietary vitamin E intake and remnant cholesterol (RC), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) using data from the National Health and Nutrition Examination Survey (NHANES). A cross-sectional analysis was conducted using NHANES 2007-2018 data. A total of 8,639 eligible participants (45.58% men and 54.42% women) with an average age of 46.12 ± 16.65 years were included in this study. Weighted multivariate linear regression and subgroup analyses were used to examine the association between vitamin E intake and RC, TC, HDL-C, and LDL-C. Smooth curve fitting was used to explore potential non-linear associations. After adjusting for other covariates, multivariate linear regression analysis showed that higher vitamin E intake was negatively associated with plasma RC (β = -0.22, 95% CI: -0.27, -0.16), TC (β = -0.33, 95% CI: -0.51, -0.16), LDL-C (β = -0.25, 95% [confidence interval] CI: -0.40, -0.10) and positively associated with HDL-C (β = 0.13, 95% CI: 0.07, 0.20) in US adults. Subgroup analysis indicated that age may influence the association between vitamin E intake and RC. At the same time, gender may also affect the association between vitamin E intake and HDL-C. Higher vitamin E intake was negatively associated with plasma RC, TC, LDL-C and positively associated with HDL-C.