Stimulation of muscarinic cholinoceptive neurons in the hippocampus evokes a pressor response with bradycardia

• Published in: Life sciences (1973) Vol. 50; no. 6; p. 427
• Main Authors: Haruta, K, Iguchi, A, Matsubara, T, Itoh, K, Chen, C L, Yoshida, S, Terada, R, Kanashiro, M, Suzuki, O, Nishimura, H
• Format: Journal Article
• Language: English
• Published: Netherlands 1992
• Subjects: Animals; Atropine Derivatives - pharmacology; Blood Pressure - drug effects; Bradycardia - physiopathology; Epinephrine - blood; Heart Rate - drug effects; Hippocampus - drug effects; Kinetics; Male; Neostigmine - pharmacology; Norepinephrine - blood; Rats; Rats, Inbred Strains; Receptors, Cholinergic - physiology; Receptors, Muscarinic - physiology

The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into...