Stimulation of muscarinic cholinoceptive neurons in the hippocampus evokes a pressor response with bradycardia

The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into...

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Published inLife sciences (1973) Vol. 50; no. 6; p. 427
Main Authors Haruta, K, Iguchi, A, Matsubara, T, Itoh, K, Chen, C L, Yoshida, S, Terada, R, Kanashiro, M, Suzuki, O, Nishimura, H
Format Journal Article
LanguageEnglish
Published Netherlands 1992
Subjects
Animals
Atropine Derivatives - pharmacology
Blood Pressure - drug effects
Bradycardia - physiopathology
Epinephrine - blood
Heart Rate - drug effects
Hippocampus - drug effects
Kinetics
Male
Neostigmine - pharmacology
Norepinephrine - blood
Rats
Rats, Inbred Strains
Receptors, Cholinergic - physiology
Receptors, Muscarinic - physiology
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Summary:The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into the hippocampus. Intrahippocampal injection of neostigmine stimulated the secretion of epinephrine and norepinephrine. Adrenodemedullation did not suppress the increase in blood pressure and the decrease in heart rate. It is concluded that the stimulation of muscarinic cholinoceptive neurons in the hippocampus evokes a hypertensive response via an increase in sympathetic drive to the heart and peripheral vasculature, with bradycardia possibly mediated via the parasympathetic system.
ISSN:0024-3205
DOI:10.1016/0024-3205(92)90377-2