Lisuride inhibits temporarily sexual behavior in female rats

The effect of lisuride (0.1 and 0.2 mg/kg IP) on the sexual behavior was studied in the adult, ovariectomized and chronically estradiol-primed female rats. The behavioral tests were done under dyadic interaction with males 60 min before and 30, 120 and 360 min after lisuride or saline injection. Lis...

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Published inPharmacology, biochemistry and behavior Vol. 27; no. 2; pp. 211 - 215
Main Author HLINAK, Z
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.06.1987
Elsevier Science
Subjects
Animals
Biological and medical sciences
Cardiovascular system
Copulation - drug effects
Ergolines - pharmacology
Estradiol
Female
Female rat
Inhibition (Psychology)
Lisuride
Lisuride - pharmacology
Lordosis response
Medical sciences
Pharmacology. Drug treatments
Posture - drug effects
Precopulatory patterns
Rats
Rats, Inbred Strains
Serotonin
Sexual behavior
Sexual Behavior, Animal - drug effects
Time Factors
Vasodilator agents. Cerebral vasodilators
Serotonin
Sexual behavior
Precopulatory patterns
Lordosis response
Lisuride
Female rat
Estradiol
Intraperitoneal administration
Serotoninergic transmission
Rat
Antimigrainous agent
Rodentia
Lordosis
Ergot derivatives
Mating
Vertebrata
Mammalia
Animal
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Summary:The effect of lisuride (0.1 and 0.2 mg/kg IP) on the sexual behavior was studied in the adult, ovariectomized and chronically estradiol-primed female rats. The behavioral tests were done under dyadic interaction with males 60 min before and 30, 120 and 360 min after lisuride or saline injection. Lisuride induced a prompt, short-termed and dose-dependent loss of the precopulatory patters (darting, hopping, presenting posture) while the effect on the copulatory (lordosis) vehavior was weaker. A partial restoration of the precopulatory behavior was observed in the 120th min, the full restoration of the original precopulatory states was found in the 360th min. The inhibitory effect of lisuride on feminine sexual behavior is in contrast with its facilitatory effect on masculine sexual behavior in rats. The results suggest that the serotonergic system participates in the mediation of both copulatory (receptive) behavior and precopulatory (proceptive) behavioral patterns.
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ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(87)90559-4