New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential "new keys for old locks" which open up an exciting field of research for well-known, but challenging important...

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Published inChemical Society reviews Vol. 48; no. 13; pp. 3497 - 3512
Main Authors Stockmann, Philipp, Gozzi, Marta, Kuhnert, Robert, Sárosi, Menyhárt B, Hey-Hawkins, Evamarie
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.07.2019
Subjects
Carborane
Icosahedral phase
Keys
Locks
Substrates
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Summary:Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential "new keys for old locks" which open up an exciting field of research for well-known, but challenging important therapeutic substrates, as demonstrated by the numerous examples discussed in this review.
Bibliography:ObjectType-Article-2
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ISSN:0306-0012
1460-4744
DOI:10.1039/c9cs00197b