The greater strength of arginine: Carboxylate over lysine carboxylate ion pairs implications for the design of novel enzymes and drugs

The rational design of enzyme catalysts for chiral chemistry and of drugs which bind to proteins would be facilitated if rules for the recognition of one partner by the other could be formulated. This communication suggests and tests one generalization: arginine forms a tighter ion pair with a carbo...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 149; no. 3; pp. 927 - 929
Main Authors Wigley, Dale B., Lyall, Andrew, Hart, Keith W., Holbrook, J.John
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 31.12.1987
Elsevier
Subjects
Amino Acid Sequence
Applied sciences
Arginine
Binding Sites
carboxylic acid groups
Chemical Phenomena
Chemistry, Physical
enzymes
Exact sciences and technology
Ions
L-Lactate Dehydrogenase
Lysine
Other techniques and industries
Protein Binding
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Summary:The rational design of enzyme catalysts for chiral chemistry and of drugs which bind to proteins would be facilitated if rules for the recognition of one partner by the other could be formulated. This communication suggests and tests one generalization: arginine forms a tighter ion pair with a carboxylate group than does lysine and is always used for ion-pairs which are not broken during turnover in naturally-occurring enzymes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(87)90497-9