Effects of rhodamine 6G on the mitochondrial ultrastructure of mouse spermatocytes

Effects of rhodamine 6G on spermatocyte mitochondria were assessed in BALB/c mice in vivo. Four groups of mice were given rhodamine 6G doses of 0.0, 0.3 and 0.5 and 0.8 mg.kg-1.d-1 i.p. for 5 days. On the 5th day after the last day of dye administration, the mice were killed and testicular tissue wa...

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Bibliographic Details
Published inToxicology letters Vol. 51; no. 1; p. 35
Main Authors Zhang, W W, Hood, R D, Smith-Sommerville, H E
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.1990
Subjects
Animals
Dose-Response Relationship, Drug
Male
Mice
Mice, Inbred BALB C
Microscopy, Electron
Mitochondria - drug effects
Mitochondria - ultrastructure
Rhodamines - pharmacology
Spermatozoa - drug effects
Spermatozoa - ultrastructure
Testis - drug effects
Testis - pathology
Xanthenes - pharmacology
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Summary:Effects of rhodamine 6G on spermatocyte mitochondria were assessed in BALB/c mice in vivo. Four groups of mice were given rhodamine 6G doses of 0.0, 0.3 and 0.5 and 0.8 mg.kg-1.d-1 i.p. for 5 days. On the 5th day after the last day of dye administration, the mice were killed and testicular tissue was prepared for electron microscopy. Exposure to rhodamine 6G resulted in dose-dependent effects, primarily intracristal expansion of mitochondria.
ISSN:0378-4274
DOI:10.1016/0378-4274(90)90222-8