Antiproliferative activity of novel benzo[ b][1,6]naphthyridines in human solid tumor cell lines

• Published in: Bioorganic & medicinal chemistry letters Vol. 20; no. 5; pp. 1504 - 1506
• Main Authors: Rudys, Simonas, Ríos-Luci, Carla, Pérez-Roth, Eduardo, Cikotiene, Inga, Padrón, José M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.03.2010; Elsevier
• Subjects: 1 H-Pyrano[4,3- b]quinolines; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibacterial drugs; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antibodies; Antifungal agents; Antifungal Agents - chemical synthesis; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antifungal drugs; Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antitumor drugs; Benzob[1,6]naphthyridines; Biological and medical sciences; Candida; Cell Line, Tumor; Drug Screening Assays, Antitumor; General aspects; Humans; Medical sciences; Multicomponent reaction; Naphthyridines - chemical synthesis; Naphthyridines - chemistry; Naphthyridines - pharmacology; Pharmacology. Drug treatments; 1 H-Pyrano[4,3- b]quinolines; Multicomponent reaction; Benzob[1,6]naphthyridines; Antitumor drugs; Antibacterial drugs; Antifungal drugs; Antineoplastic agent; Solid tumor; Lung; Uterine cervix; 1H-Pyrano[4,3-b]quinolines; Fungi; Antifungal agent; Chlorine Organic compounds; Fungi Imperfecti; Colon; Chemical synthesis; Tumor cell; Endometrium; Human; Malignant tumor; In vitro; Hela cell line; Biological activity; Cell line; Candida; Antibacterial agent; Cancer
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2010.01.112

The synthesis and antiproliferative activity of novel 1,2-dihydro-3-phenyl-1-(trichloromethyl)benzo[ b][1,6]naphthyridines is reported. A series of 2-substituted 1,2-dihydro-3-phenyl-1-(trichloromethyl)benzo[ b][1,6]naphthyridines were synthesized and their in vitro antiproliferative activities were examined against human solid tumor cell lines and relevant strains of bacteria and Candida. The compounds induced considerably growth inhibition in all cancer cell lines, whilst showed inactive against microbial strains. Furthermore, we found analog 2-ethoxy-1 H-pyrano[4,3- b]quinoline as selective inhibitor of microbial strains.