Combined sentinel lymph-node mapping and bone-marrow micrometastatic analysis for improved staging in breast cancer

• Published in: The Lancet (British edition) Vol. 354; no. 9173; pp. 129 - 130
• Main Authors: Relihan, N, McGreal, G, Kelly, J, Ryan, D, O'Sullvan, GC, Redmond, HP
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 10.07.1999; Lancet; Elsevier Limited
• Subjects: Axilla; Biological and medical sciences; Bone marrow; Bone Marrow Neoplasms - pathology; Bone Marrow Neoplasms - secondary; Breast cancer; Breast Neoplasms - pathology; Female; Genital system. Mammary gland; Humans; Ilium; Investigative techniques, diagnostic techniques (general aspects); Lymph Nodes - pathology; Lymphatic Metastasis - diagnosis; Lymphatic system; Medical sciences; Neoplasm Staging - methods; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Prospective Studies; Ribs - pathology; Human; Cartography; Carcinoma; Lymph node; Aspiration; Hemopathy; Malignant tumor; Metastasis; Bone marrow disease; Mammary gland diseases; Association; Microscopy; Bone marrow; Female; Developmental stage; Diagnosis; Mammary gland; Iliac crest
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(99)02664-1

In a prospective study of 29 patients with clinically node-negative breast cancer, sampling of rib marrow was superior to sampling of iliac-crest marrow for detection of micro-metastases. Combination of marrow micrometastatic analysis with sentinel lymph-node mapping may improve accuracy of staging in breast cancer.