The effect of ketanserin on serotonin-induced vascular responses in the isolated perfused rat lung

Based on a vasoconstrictor role for serotonin (5-HT) in various types of cardiopulmonary conditions the effect of the 5-HT2 receptor antagonist, ketanserin, on 5-HT-induced responses in the intact, isolated rat lung was investigated. 5-HT produced biphasic responses consisting of weak vasodilator an...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of pharmacology Vol. 169; no. 2-3; p. 269
Main Authors Le Roux, M G, Syce, J A
Format Journal Article
LanguageEnglish
Published Netherlands 10.10.1989
Subjects
Animals
Blood Pressure - drug effects
Dose-Response Relationship, Drug
In Vitro Techniques
Ketanserin - pharmacology
Male
Muscle, Smooth, Vascular - drug effects
Pulmonary Circulation - drug effects
Rats
Rats, Inbred Strains
Serotonin - pharmacology
Vasoconstriction - drug effects
Online AccessGet more information

Cover

More Information
Summary:Based on a vasoconstrictor role for serotonin (5-HT) in various types of cardiopulmonary conditions the effect of the 5-HT2 receptor antagonist, ketanserin, on 5-HT-induced responses in the intact, isolated rat lung was investigated. 5-HT produced biphasic responses consisting of weak vasodilator and predominant, dose-dependent constrictor components. Ketanserin showed no direct vasodilator effects but could completely antagonise the 5-HT-induced vasoconstrictor responses, suggesting that this response was 5-HT2 receptor-mediated.
ISSN:0014-2999
DOI:10.1016/0014-2999(89)90024-1