Comprehensive delineation of antigenic and immunogenic properties of peptides derived from the nef HIV-1 regulatory protein

• Published in: Vaccine Vol. 11; no. 11; pp. 1083 - 1092
• Main Authors: Estaquier, J., Boutillon, C., Gras-Masse, H., Ameisen, J.-C., Capron, A., Tartar, A., Auriault, C.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1993; Elsevier
• Subjects: Ag presentation; AIDS/HIV; Amino Acid Sequence; Antigenic determinants, haptens, artificial antigens; Antigens; Antigens, Viral - immunology; B- and T-cell epitopes; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Products, nef - immunology; HIV; HIV-1 - immunology; human immunodeficiency virus 1; Humans; Molecular immunology; Molecular Sequence Data; nef Gene Products, Human Immunodeficiency Virus; Peptide Fragments - immunology; synthetic peptides; Ag presentation; synthetic peptides; HIV; B- and T-cell epitopes; Virus; Proteins; Antigen presentation; Synthetic product; Antigenicity; Antigenic determinant; Immunogenicity; HIV-1 virus; Retroviridae; Lentivirinae; Human immunodeficiency virus; Review
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/0264-410X(93)90066-7

The Human Immunodeficiency Virus (HIV-1) nef regulatory protein, a protein involved in AIDS pathology, was used as a model to investigate and analyze B- and T-cell epitopes. In this paper, we describe the potential structural basis of antigenic and immunogenic reactivity of synthetic peptides derived from the macromolecular antigen. The relationship between B- and T-cell determinants in the context of regulatory mechanisms involved in immune recognition, while integrating recent data concerning MHC presentation. As a result of the recent progress in the field of peptide recognition and presentation, the potential of the peptide approach for constructing successful synthetic vaccines needs to be continuously re-evaluated.