A balanced brain asymmetry modulates T cell-mediated events

• Published in: Journal of neuroimmunology Vol. 5; no. 3; pp. 227 - 238
• Main Authors: Renoux, Gérard, Biziere, Kathleen, Renoux, Micheline, Guillaumin, Jean-Maurice, Degenne, Danielle
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 01.01.1983; Amsterdam Elsevier; New York, NY
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Animals; Biological and medical sciences; Brain lateralization; Cell interactions; Cerebral Cortex - immunology; Cognitive processes; Dominance, Cerebral; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Immune recognition; Immunity, Cellular; Immunobiology; Leukocyte Count; Mice; Mice, Inbred C3H; NK activity; Organismic asymmetry; Rodents; Serum factors; Spleen - immunology; T cell function; T cell number; T-Lymphocytes - immunology; T cell number; Serum factors; Cognitive processes; Organismic asymmetry; T cell function; Brain lateralization; Rodents; Immune recognition; NK activity; Rodentia; Central nervous system; Brain(Invertebrata); IgG; Immune regulation; B-Lymphocyte; Natural killer cell; Vertebrata; Specificity; Mammalia; Mouse; Immune stimulation; Animal; T-Lymphocyte; Mitogen; Laterality; Serum factor; Macrophage
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/0165-5728(83)90043-7

Partial ablation of the left fronto-parietal cerebral cortex decreases the number of spleen T cells, impairs IgG-α SRBC and T mitogen-induced responses, and delays the response to alloantigens. In contrast, these events are increased following a symmetric lesion of the right neocortex. The findings extend previous results showing that the neocortex modulates NK activity and the efficacy of T cell-specific serum factors. B cells and macrophages are not affected. In these assays, mice subjected to ablation of one lateral cerebral neocortex serve as controls for symmetrically lesioned mice, in addition to no surgery or sham-operated controls. The findings suggest that brain lateralization for cognitive processes should be extended to T cell immune recognition. The phenomenon is present at a population level.