Lamina-specific arrangement of astrocytic gliosis and senile plaques in Alzheimer's disease visual cortex

Alzheimer's disease (AD) visual cortex (area 17) was investigated using stains for plaques and tangles (Bielschowsky, thioflavine S) and gliosis (GFAP immunoperoxidase). Pathology was heaviest in layers II, III, IVa and IVc. Of especial interest was a thin line of plaques and astrocytic gliosis...

Full description

Saved in:
Bibliographic Details
Published inBrain research Vol. 463; no. 2; p. 357
Main Authors Beach, T G, McGeer, E G
Format Journal Article
LanguageEnglish
Published Netherlands 01.11.1988
Subjects
Aged
Aged, 80 and over
Alzheimer Disease - complications
Alzheimer Disease - pathology
Astrocytes - metabolism
Astrocytes - pathology
Glial Fibrillary Acidic Protein - analysis
Gliosis - etiology
Gliosis - pathology
Humans
Immunohistochemistry
Middle Aged
Neurofibrils - pathology
Visual Cortex - pathology
Online AccessGet more information

Cover

More Information
Summary:Alzheimer's disease (AD) visual cortex (area 17) was investigated using stains for plaques and tangles (Bielschowsky, thioflavine S) and gliosis (GFAP immunoperoxidase). Pathology was heaviest in layers II, III, IVa and IVc. Of especial interest was a thin line of plaques and astrocytic gliosis at the lower margin of layer IVc. These results could provide an insight into the pathogenesis of AD, and suggest that patients with AD may have specific visual deficits.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(88)90410-6