Accessory olfactory bulb transplants correct hypogonadism in mutant mice

Transplantation of normal fetal gonadotropin-releasing hormone (GnRH) neurons from the accessory olfactory bulb (AOB) to the third ventricle of GnRH-deficient adult mutant mice reverses the genetically determined reduction in pituitary hormones and poorly developed gonads. The transplanted heterotop...

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Bibliographic Details
Published inBrain research Vol. 415; no. 1; p. 158
Main Authors Perlow, M J, Kokoris, G, Gibson, M J, Silverman, A J, Kreiger, D T, Zimmerman, E A
Format Journal Article
LanguageEnglish
Published Netherlands 07.07.1987
Subjects
Animals
Cerebral Ventricles - metabolism
Cerebral Ventricles - physiopathology
Cerebral Ventricles - surgery
Fetus
Graft Survival
Hypogonadism - physiopathology
Hypothalamus - metabolism
Hypothalamus - physiopathology
Luteinizing Hormone - blood
Male
Mice
Mice, Mutant Strains
Olfactory Bulb - physiopathology
Olfactory Bulb - transplantation
Organ Size
Pituitary Gland - metabolism
Pituitary Hormone-Releasing Hormones - physiology
Testis - pathology
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Summary:Transplantation of normal fetal gonadotropin-releasing hormone (GnRH) neurons from the accessory olfactory bulb (AOB) to the third ventricle of GnRH-deficient adult mutant mice reverses the genetically determined reduction in pituitary hormones and poorly developed gonads. The transplanted heterotopic AOB neurons adapt their morphology and secretory functions to what is observed with preoptic GnRH neurons when transplanted into deficient mice and in the normal intact mature animal. This suggests the presence of median eminence trophic factors affecting the growth, terminal sprouting, and functional behavior of the transplanted neurons.
ISSN:0006-8993
DOI:10.1016/0006-8993(87)90280-0