Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome

• Published in: Neuroscience letters Vol. 208; no. 2; pp. 117 - 120
• Main Authors: Vecchiet, Leonardo, Montanari, Giuseppe, Pizzigallo, Eligio, Iezzi, Sabina, de Bigontina, Paolo, Dragani, Luca, Vecchiet, Jacopo, Giamberardino, Maria Adele
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 19.04.1996; Elsevier
• Subjects: Adult; Biological and medical sciences; Biopsy; Chronic fatigue syndrome (CFS); Diseases of striated muscles. Neuromuscular diseases; Electric Stimulation; Fatigue Syndrome, Chronic - physiopathology; Female; Humans; Male; Medical sciences; Microscopy, Electron; Middle Aged; Muscle; Muscle biopsy; Muscle, Skeletal - innervation; Muscle, Skeletal - pathology; Muscle, Skeletal - ultrastructure; Neurology; Pain Threshold - physiology; Pain thresholds; Parietal Lobe - physiology; Skin; Skin - innervation; Somatosensory Cortex - physiology; Subcutis; Skin; Muscle; Subcutis; Chronic fatigue syndrome (CFS); Pain thresholds; Muscle biopsy; Human; Pain; Striated muscle; Biopsy; Perception threshold; Chronic fatigue syndrome
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/0304-3940(96)12559-3

Patients with chronic fatigue syndrome (CFS) mainly complain of symptoms in the musculoskeletal domain (myalgias, fatigue). In 21 CFS patients the deep (muscle) versus superficial (skin, subcutis) sensitivity to pain was explored by measuring pain thresholds to electrical stimulation unilaterally in the deltoid, trapezius and quadriceps and overlying skin and subcutis in comparison with normal subjects. Thresholds in patients were normal in skin and subcutis but significantly lower than normal (hyperalgesia) in muscle ( P < 0.001) in all sites. The selective muscle hypersensitivity corresponded also to fiber abnormalities at muscle biopsy (quadriceps) performed in nine patients which were absent in normal subjects (four cases): morphostructural alterations of the sarchomere, fatty degeneration and fibrous regeneration, inversion of the cytochrome oxidase/succinate dehydrogenase ratio, pleio/polymorphism and monstruosity of mitochondria, reduction of some mitochondrial enzymatic activities and increments of common deletion of 4977 bp of mitochondrial DNA 150–3000 times the normal values. By showing both sensory (diffuse hyperalgesia) and anatomical (degenerative picture) changes at muscle level, the results suggest a role played by peripheral mechanisms in the genesis of CFS symptoms. They would exclude the heightened perception of physiological signals from all districts hypothesized by some authors, especially as the hyperalgesia is absent in skin/subcutis.